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A recent study has demonstrated that the inhibition of Nrf2 signalling could significantly promote the incidence of type I diabetes mellitus, and, on the other hand, its reactivation reduces oxidative stress in pancreatic -cells [143]

Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219

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This timepoint was pre-specified to maximize the number observable while allowing sufficient duration of follow-up to evaluate the treatment effect reliably